How does the body fight with melanoma?

Here is a short (1min) and simplified video describing my project and some of the main results I have obtained so far. During my PhD, one of my research focus was to understand how melanoma can hide from the body’s defence mechanism, which is called the immune system. In my analyses,Read More

Understanding familial melanoma

  This is a brief video summarising my PhD project (ESR01) at the Wellcome Sanger Institute in Cambridge, UK.  It involves the sequencing and analysis of familial melanoma patients from across the world. To learn more, please read my blog post on the topic linked here. – Aravind Sankar (ESR01),Read More

Can we slow down skin cancer progression?

The progression from benign cells to melanoma is not fully understood. In addition to genetic alterations, some epigenetic mechanisms, the ones that do not involve DNA sequence, play a role in the development and evolution of melanoma. My PhD project aims to disclose the epigenetic features behind melanoma progression. WeRead More

Are my genes contributors to melanoma?

  Looking to learn more about genes as contributors to cancer development? This is a short clip about melanoma genetics and the PhD project I have been working on for the past 3 years as part of the MelGen European training network! I aim to understand how the riskRead More

Liquid biopsy for the assessment of metastatic melanoma

Liquid biopsy employs the analyses of circulating cell-free DNA (ctDNA). ctDNA can be found in the plasma, and it provides a non-invasive approach in the assessment of metastatic melanoma. Moreover, it allows for real-time monitoring of progression or response to therapies. ctDNA is a promising predictive biomarker, that hasRead More

Vitamin D and melanoma

By Sathya Muralidhar, University of Leeds Is vitamin D- the ‘sunshine’ vitamin, linked to melanoma? My research shows that vitamin D and its ‘partner’- Vitamin D Receptor (VDR for short) are both involved in melanoma growth and response of the immune system. Using genomic data (DNA-level information) from melanomaRead More

Understanding Health Through Your Genome

Genetics and Your Genome Genetics, the scientific study of DNA has revealed important insights about processes in the human body, how it becomes susceptible to diseases as well as how it responds to medications when suffering from a disease. To recall, genes which are the basic physical and functionalRead More

Can people of dark skin colour get melanoma?

“Can people of dark skin colour get melanoma?’’ More than often this question reflects inherent disbelief and skepticism since people of dark skin colour do report much less incidence of melanomas, for example melanomas only account for 1-8% skin malignancies in people of black complexion whereas for Asian IndiansRead More