Familial melanoma: Risk of disease as an inherited disorder

It is now widely appreciated that cancer may arise from multifactorial contributors both genetic and environmental. In approximately 10% of melanoma cases multiple family members are affected. Familial melanoma defines the occurrence of 3 or more melanomas in a family, 2 of which are found in first-degree relatives (Figure1).Read More

It’s all in the genes

While the majority of cancers are not hereditary, some do occur multiple times within the same family. A well-known example of this is breast cancer, where mutations in the BRCA genes (BRCA1/BRCA2) predispose to breast cancer, with notable patients including Angelina Jolie. Melanoma, too, can sometimes be passed fromRead More